基础医学院生物化学与分子生物学系
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    陈蔚文 首页 >> 师资队伍 >> 副教授 >> 陈蔚文

    陈蔚文

    • 副教授 硕士研究生导师

    • 联系地址:济南市文化西路44号 山东大学医学院 生化与分子研究所 250012电话:86-531-88282092-8 E-mail:chenweiwen@sdu.edu.cn



    个人简介 代表著作 科研项目 我们的实验室

    学习与工作经历

    2005.9~2008.6 山东大学 生物化学与分子生物学 博士
    1998.9~2001.6 山东大学 生物化学与分子生物学 硕士
    1991.9~1996.6 山东大学(原山东医科大学) 临床医疗 学士
    科研概述

    目前主要兴趣方向为肿瘤分子生物学研究,重点是肺癌和前列腺癌相关基因的表达调控机制和功能

    教学
    •  医学分子生物学(五、七、八年制)

    •  临床生化与分子生物学(五、七、八年制)

    •  现代分子生物学技术的基本原理与应用(研究生)

    •  细胞及分子生物学综合实验(五、七年制)




    代表著作

    1. Weiwen Chen, Weifang Wu, Jian Zhao,Chunxiao Yu, Wenwen Liu, Anli Jiang, Jianye Zhang. Molecular cloning and preliminary analysis of the human alpha-methylacyl-CoA racemase promoter. Mol Biol Rep, 2009, 36(3): 423-430 (SCI)

    2. Jian Zhao, Nana Ni, Chang Liu, Pengju Zhang, Yang Yu, Zhaobo Chen, Weiwen Chen (通信作者) and Anli Jiang. Cloning and characterization of the 5' flanking region of microRNA let-7a-1/let-7f-1 gene cluster in human lung cancer cell. African Journal of Biotechnology Vol. 10(46), pp. 9233-9241

    3. CHEN Weiwen, ZHANG Jianye, Charles Y F Young, ZHANG Lianying , CHEN Liucun, ZHAO Jian. The RFA regulatory sequence-binding protein in the promoter of prostate-specific antigen gene. Science in China (Series C), 2003, 46: 184-93 (SCI)

    4. Meilan He, Weiwen Chen, Pengju Zhang, Anli Jiang, Wei Fan, Huiqing Yuan,Wenwen Liu, Jianye Zhang.Gum mastic increases maspin expression in prostate cancer cells.Acta Pharmacol Sin. 2007,28:567-72(联合第一)(SCI).

    5. Shi P, Chen WW, Hu XY, Yu CX, Zhang PJ, Jiang AL, Zhang JY. Up-regulates the expression of maspin gene in prostate cancer cell line LNCaP. Yao Xue Xue Bao. 2006 Dec;41(12):1152-6.Chinese.(联合第一).

    6. Wenwen Liu, Weiwen Chen, Pengju Zhang, Chunxiao Yu, Feng Kong, Jingti Deng, Jianye Zhang, Aanli Jiang. Molecular cloning and analysis of the human PCAN1 (GDEP) promoter.Cell Mol Biol Lett, 2007, 12:482-92. (SCI).

    7. Yu CX, Jin T, Chen WW, Zhang PJ, Liu WW, Guan HY, Zhang J, Liu QW, Jiang AL. Identification of Sp1-elements in the promoter region of human homeobox gene NKX3.1. Mol Biol Rep. 2009 Nov;36(8):2353-60. Epub 2009 Mar 5. (SCI).

    8. Liu W, Zhang P, Chen W, Yu C, Cui F, Kong F, Zhang J, Jiang A. Characterization of two functional NKX3.1 binding sites upstream of the PCAN1 gene that are involved in the positive regulation of PCAN1 gene transcription. BMC Mol Biol. 2008 May 4;9:45. (SCI).

    9. Xiao-Qian Zhang, Jian-Ye Zhang. Effects of 9-cis retinoic acid on human homeobox gene NKX3.1 expression in prostate cancer cell line LNCaP. Asian Journal of Andrology,2006 Jul;8(4):435-41(SCI).

    10.HuiqingYuan, Jianye Zhang. Identification of an inhibitory cis-element in the promoter region of human homeobox gene NKX3.1. Prostate,2006,66:1339-46(SCI).

    11. Deng, Jianye Zhang, Charles Yufu Young.Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP.Acta Pharmacol Sin, 2007,28:423-30(SCI).

    12.Pengju Zhang, Jianye Zhang, Charles Y. F. Young, Pai C. Kao, Weiwen Chen, Anli Jiang, Lianying Zhang, and Qiang Guo. Decoy Androgen-Responsive Element DNA can inhibit androgen receptor transactivation of the PSA promoter gene. Annals of clinical & laboratory science, 2005, 35: 278~83(SCI).

    13.An-li Jiang, Peng-ju Zhang, Xiao-yan Hu, Wei-wen Chen, Feng Kong, zhi-fang LIU, Hui-qing YUAN, and Jianye Zhang. identification of Positive cis-element upstream of human NKX3.1 gene. Acta Biochimica et Biophysica Sinica. 2005, 37(11): 773-778 (SCI).

    13.Zhang P, Liu W, Zhang J, Guan H, Chen W, Cui X, Liu Q, Jiang A. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. Mol Biol Rep. 2010 Mar;37(3):1505-12. Epub 2009 May 22. (SCI).

    14.Li-Na Wang*, Wei-Wen Chen*, Ju Zhang, Chao-Yang Li, Chun-Yan Liu, Jing Xue, Peng-Ju Zhang and An-Li Jiang. The miRNA let-7a1 inhibits the expression of insulin-like growth factor 1 receptor (IGF1R) in prostate cancer PC-3 cells. Asian J Androl. 2013 Nov;15(6):753-8 (联合第一)






    科研项目

    1. 两个肺癌治疗新靶点:Wnt信号通路和miRNA let-7a-2的相互关系研究,山东省博士基金,结题

    2. p53对前列腺癌细胞中抑丝酶基因maspin的表达调控,国家自然基金面上项目,结题

    3. lincRNA-ETS1-2上调癌基因ETS-1表达促进雄激素非依赖性前列腺癌演进的机制, 国家自然基金面上项目,在研

    3.lincRNA-ETS1-2上调癌基因ETS-1表达促进雄激素非依赖性前列腺癌演进的机制,国家自然基金面上项目,在研







     

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    地址:山东省济南市文化西路44号  邮编:250012