教授 博士研究生导师

地址：山东省济南市历下区文化西路44号 山东大学基础医学院

邮编：250012

电话: 0531-88382346-602

邮箱: jianli08@sdu.edu.cn

个人简介

2018.07            山东大学          基础医学院            教授

2016.09-2018.06    斯坦福大学        医学院               博士后

2008.09-2013.07    清华大学          生命科学学院         博士

2003.09-2006.07    华中科技大学      环境科学与工程学院   硕士

1999.09-2003.07    华北水利水电大学  环境工程系           本科

科研概述

本团队主要研究领域围绕细胞内胆固醇转运、代谢以及胆固醇对细胞信号通路的调节机制进行研究。聚焦于疾病中 胆固醇代谢紊乱及其导致的胆固醇应激压力响应的分子机制，筛选胆固醇代谢相关基因，进而通过药物设计以及基因组编辑等干预手段为胆固醇代谢疾病提供治疗策略。

发表的文章

Jian Li*, Peter L. Lee*, Suzanne R. Pfeffer. Quantitative Measurement of Cholesterol in Cell Populations Using Flow Cytometry and Fluorescent Perfringolysin O. Methods Mol Biol. 2017, 1583. (*equal contribution).

Jian Li, Suzanne R. Pfeffer. Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export. Elife. 2016, 5: e21635.

Xiaochun Li*, Piyali Saha*, Jian Li*, Guntel Blober, Suzanne R. Pfeffer. Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle luminal domain bound to NPC2. PNAS. 2016, 113 (36). (*equal contribution).

Jian Li*, Maika S. Deffieu*, Peter L. Lee*, Piyali Saha, Suzanne R. Pfeffer. Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells. PNAS. 2015, 112 (48). (*equal contribution).

Chen Sun*, Jian Li*, Yu Cao, Gongbo Long, Bing Zhou. Mitochondria-and heme-mediated cellcidal pathways are two distinct actions of the antimalarial drug artemisinins. Microbial Cell. 2015, 2 (1). (*equal contribution).

Yue Feng*, Wenfei Li*, Jian Li*, Jiawei Wang, Jingpeng Ge, Duo Xu, Yanjing Liu, Kaiqi Wu, Qingyin Zeng, Jiawei Wu, Changlin Tian, Bing Zhou & Maojun Yang. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012; 491, 478-482. (*equal contribution). 

Jian Li, Bing Zhou. Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies. Molecules. 2010; 15(3): 1378-1397.

Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Ying Li, Bing Zhou. Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation. PLoS ONE. 2010; 5(3): e9582.

Kai-Hong Zhao, Ping Su, Jian Li, Jun-Ming Tu, Ming Zhou, Claudia Bubenzer, Hugo Scheer. Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin: cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120. J Biol Chem. 2006; 281(13): 8573-81.