孙金鹏-山东大学基础医学院生物化学与分子生物学系

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孙金鹏

孙金鹏，教授，博士生导师；国家杰出青年基金获得者（药理学）
政治面貌，党员
联系地址：济南市文化西路44号山东大学医学院生化与分子研究所 250012
电话：86-531-88381910 传真: 0531-88382502
E-mail：sunjinpeng@sdu.edu.cn; jinsun@receptor-biol.duke.edu; sunjinpengsdu@126.com

个人简介代表著作科研项目我们的实验室

个人简介

1993-1998年，中国科学技术大学，获得生物学和计算机科学双学位；2001-2007年，美国爱因斯坦医学院分子药理学专业，获得博士学位；2007-2011年，在杜克大学Robert J Lefkowitz教授(2012年GPCR领域诺贝尔化学奖)实验室从事膜受体GPCR的相关研究。

孙金鹏长期从事膜受体G蛋白偶联受体（GPCR）的相关研究，在美国留学10年后回国建立了独立研究团队。回国后，聚焦于GPCR功能多样性的细胞机制以及针对GPCR的药物发展，立足国内，发展了Arrestin所介导的GPCR偏向性信号转导的药理学理论，阐明了GPCR偏向性在胰岛素分泌和糖代谢中的调控功能，并开发了系列偏向性干预策略。回国后，（1）发现了GPR97是糖皮质激素的膜受体，介导糖皮质激素的快速信号转导，从而为陈宜张教授早年发现的糖皮质激素非核受体功能提供了重要的理论支持；鉴定了粘附类受体GPR126内源性配体孕酮和17-OHP，阐明孕酮可以通过激活GPR126促进三阴性乳腺癌的发生和发展；首次发现血管紧张素受体的内源性别构调节因子COMP及高同半胱氨酸可以直接激活AT1R等（Nature 2021，PNAS 2022，Cell Research 2021, Nature Commun 2017, Nature Commun 2021）；（2）创新性地提出了GPCR磷酸化编码的“笛子模型”（Nature Commun 2015，Faculty 1000专题评论, Nature Commun 2021, PNAS 2021），多聚脯氨酸码头分选及别构建调控理论（Nature Chem Biol 2018）,以及证明了配体依赖的受体7次跨膜核心可以对Arrestin功能的指导（Nature Commun 2020，Faculty 1000专题评论），并可应用新模式发展磷酸酶抑制剂，从而有效地操控受体的磷酸化编码的新理念（Cell Research 2014，Cell Reports 2016，获2014年Cell Research的专题评论），为GPCR的偏向性药物开发奠定了理论基础；（3）解析了GPCR感知痒觉，力学以及多种配体的编码机制。揭示了痒觉受体识别多种配体的机制以及独特的激活模式，阐明了痒感觉得重要机制，完美地解决了该领域多年以来的困惑，这项研究无疑为瘙痒的治疗提供了广阔的发展前景。（Nature. 2021;600(7887):164-169）以黏附受体作为模型进行功能和结构的分析，用实验证明了受体感知机械力后通过Stachel序列激活受体，并进一步确定了Stachel中的5个疏水氨基酸组成的保守HIM（Fss-03xφφφxφss-09）在Stachel序列与受体相互作用中起着核心作用，并据此机制发展了黏附类受体通用多肽激动剂和拮抗剂（Nature. 2022a, Proof received on 2022/03/25; Nature. 2022b, Proof received on 2022/03/17）（4）发现了GPCR区域性信号转导中Arrestin偏好性激活离子通道的一种非G蛋白依赖的全新快速机制，打破了人们对GPCR信号转导的固有认识（Nature Commun 2017（杂志专题评论）；Nature Commun 2018）；揭示了黏附类受体在顶膜区域信号转导对重吸收的调控作用（Elife 2018, Faculty 1000专题评论）；（5）阐明了多个GPCR对胰岛功能，糖代谢和体外组织再造的调控作用，为进一步靶向GPCR偏向性信号途径的药物设计提供了指导（Cell Metabolism 2022，同期杂志preview专题评论；Biol Psychiatry 2017，封面文章，Faculty 1000专题评论， Diabetologia 2014，Br J Pharmacol 2015）；（6）阐明了快乐激素多巴胺受体以及肝肠轴枢纽胆汁酸受体识别其内源性配体，及偏好性信号转导的结构基础以及痒觉感知的分子机制 (Nature 2020，2021， Cell 2021, 封面文章）；（7）建立了靶向GPCR偏向性信号途径的Aptamer和小分子抑制剂的开发方法，获得了一系列GPCR的偏好性配体以及GPCR下游磷酸酶的特异性抑制剂（Future Med Chem 2015，J Med Chem 2014）。

在该领域，孙金鹏教授已在Nature，Cell，Nature Medicine, Cell Metabolism，Nature Chemical Biology, Nature Communications，PNAS，Cell Research，Elife, Cell Reports等SCI收录杂志发表110余篇文章，总影响因子800余，文章总引用次数3000余次；回国后通讯作者文章59篇，影响因子合计737，引用次数总计600余次；其中24篇通讯作者文章影响因子大于10，7篇通讯文章被Faculty1000专门推荐，3篇通讯获得杂志的专题评述，3篇通讯文章被选为杂志封面。鉴于上述研究成果，申请人受邀在药理学相关杂志Mol Pharm，J Neuro Chem，Int J Biochem Cell Biol等撰写综述，并应邀在关于G蛋白偶联受体的药理学研究的双清论坛（2014），全国化学生物学大会（2015），全国受体专业委员会（2016，2017）；全国生物化学与分子生物学药理学会（2017），全国肾脏药理学会（2017），中美药理学会（2017），亚洲药学会（2017）和第17届嗜铬细胞国际大会（2017，英国）等会议进行专题报告；获得2015年山东省高等学校优秀科研成果奖一等奖等。

教育经历

1993年－1998年，单位，中国科学技术大学生命科学院生物学，计算机科学,双学士

1998年－2001年，单位，中国科学技术大学生命科学院，硕士

2001年－2007年，单位，阿尔伯特.爱因斯坦医学院/Albert Einstein College of Medicine 博士，导师，张仲寅（Zhong-yin, Zhang）

2007年－2011年，单位，杜克大学/Duke University 博士后导师 Robert j. Lefkowitz; James B. 杜克大学药物及生物化学教授，美国科学院院士，邵逸夫奖获得者2007，美国自然科学奖获得者2008，HHMI，2012诺贝尔奖获得者。

工作经历

2021年-今山东大学高等医学研究院常务副院长

2020年-今山东大学基础医学院，党委委员

2016年12月-今山东大学基础医学院，生化与分子生物学系教授，系主任。

博士生导师，齐鲁青年学者

2011年1月-今生化与分子生物学系教授，博士生导师，齐鲁青年学者

学术任职

孙金鹏教授目前担任中国生理与病理学术委员会委员，生理与病理协会青年委员会副主任委员，受体与离子通道专业委员会副主任委员；脂质与脂蛋白委员会委员；中国病理生理学会受体专业委员会委员；中国药理学会肾脏专业委员会常务委员；中国干细胞生理专业委员会委员，中国生化与分子药理学会专业委员会委员，中国听觉与听觉障碍专业委员会委员等。担任教育部长江学者，教育部博士点基金评委；教育部科技奖励评委；博士后基金评委；国家自然科学基金面上，重点，国际合作，杰青，优青一审，二审评委。

学术论文审稿人：

《Nature》；《Science》; 《Cell》; 《Nature Chemical Biology》;《Nature Structural & Molecular Biology》；《Biochemistry》；《Journal of Neurochemistry》；《J Biol Chem》；《Cell Research》;《Molecular Pharmacology》；《Biochemical Journal》；《CMLS》。

获奖：

中国生物化学与分子生物学会第十一次（2014）“青年科学家论坛”一等奖

2015年山东省高等学校优秀科研成果奖（2015）普通本科自然科学类一等奖，

成果名称：靶向G蛋白偶联受体和磷酸酶的药理学研究孙金鹏第一位

回国后作为通讯作者发表的论文

1. Xiao-Yan Ge, Jie Cheng, Li-Jun Zhang, Lu-Lu Guo, Rui Xiang, Yan Lu, Shang-Lei Ning, Kai-Yu Wang, Kong-Kai Zhu, Ming-Xin Gao, Yue Li, Yu-Song Zhang, Nai-Kang Rong, Xiang Han, Ming-Hui Zhang, Le Fang, Yun-Fei Xu, Su-Wen Zhao, Qian Li, Fan Yang, Yong Hao^#, Ren-Jie Chai^#, Xiao Yu^#, Ji-Chun Yang^#, and Jin-Peng Sun^#. Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target. Cell. 2026 Jan 21:S0092-8674(25)01429-1. 最后通讯作者。

2. Xiang Han, Ming-Hui Zhang, Nai-Kang Rong, Kong-Kai Zhu, Yuan Pei, Xiao-Yan Ge, Qi Liu, Huan Lu, Jing Liu, Li-Jun Zhang, Hong-Qiang Bao, Jia-Hao Pi, Lei Fan, Yu Fu, Xu-Hang Shao, Wen-Qi Yan, Xi-He Gao, Ming-Yue Zhang, Lu-Lu Guo, Yan Lu, Shang-Lei Ning, Hua Zhang, Yun-Fei Xu, Xiao-Ya Feng, Jie Cheng, Ming Xia^#, Qian Li^#, Xiao Yu^#, Fan Yang^#, and Jin-Peng Sun^#. Mechanistic insights into fatty acid odor detection mediated by class II olfactory receptors. Cell. 2026 Jan 21:S0092-8674(25)01431-X. 最后通讯作者。

3. Jia-Le Wang, Xue-Ying Sha, Yue Shao, Zi-Hao Zhang, Shen-Ming Huang, Hui Lin, Shi-Yi Gan, Nan Zhang, Xin-Yi Xia, Yu-Nan Sun, Jin-Hui Ding, Rui-Qi Zhao, Jie Cheng, Pan Shang, Jin-Peng Wang, Yan-Jun Liu, Fan Yang, Peng Xiao, Lu-Wen Wang, Dong-Yu Zhao, Yi Tang, Lu Tie, Yang Du, Yong Zhang, Ju-Fang He, and Jin-Peng Sun^#. Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment. Cell. 2026 Jan 22;189(2):640-658.e22. 最后通讯作者。

4. Wen-Qin Xiao, Yan Zhu, Xin-Jie Tang, Kong-Kai Zhu, Wei-Feng Zhang, Meng-Ting Chen, Kui Cai, San Xu, Zheng Wu, Mei Wang, Jia-Yi Liu, Ling-Long Long, Zi-Xin Tan, Ai-Ke Wu, Song-Qi Zhou, Zhi-Xiang Zhao, Yan Tang, Ying-Xue Huang, Ben Wang, Fang-Fen Liu, Qian Wang, Fan Yang, Dan Jian, Wei Shi, Hong-Fu Xie, Xiang Chen, Lu-Lu Guo^#, Zhi-Li Deng^#, Jin-Peng Sun^#, and Ji Li^#, Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema, Cell. 2026. 通讯作者，倒数第二位。

5. Zhao Yang, Yu-Qi Ping, Ming-Wei Wang, Chao Zhang, Shu-Hua Zhou, Yue-Tong Xi, Kong-Kai Zhu, Wei Ding, Qi-Yue Zhang, Zhi-Chen Song, Ru-Jia Zhao, Zi-Lu He, Meng-Xin Wang, Lei Qi, Christian Ullmann, Albert Ricken, Torsten Schöneberg, Zhen-Ji Gan, Xiao Yu^#, Peng Xiao^#, Fan Yi^#, Ines Liebscher^#, and Jin-Peng Sun^#. Identification, structure, and agonist design of an androgen membrane receptor. Cell. 2025 Mar 20;188(6):1589-1604.e24. 最后通讯作者，引用2次。

6. Hui Lin, Chuanshun Ma, Kui Cai, Lulu Guo, Xuemei Wang, Lin Lv, Chao Zhang, Jun Lin, Daolai Zhang, Chuan Ye, Tengwei Wang, Shenming Huang, Jifei Han, Zihao Zhang, Junyan Gao, Mingxiang Zhang, Zhao Pu, Fengyang Li, Yongyuan Guo, Xiaojun Zhou, Chengxue Qin, Fan Yi, Xiao Yu^#, Wei Kong^#, Changtao Jiang^#，Jin-Peng Sun^#. Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis. Science. 2025 May;388(6746):eado4188.最后通讯作者。

7. Siting Zhang, Hui Lin, Jiale Wang, Jingyu Rui, Tengwei Wang, Zeyu Cai, Shenming Huang, Yanxiang Gao, Tianfeng Ma, Rui Fan, Rongbo Dai, Zhiqing Li, Yiting Jia, Qiang Chen, HaoMing He, Jiaai Tan, Shirong Zhu, Rui Gu, Zhigang Dong, Meihong Li, Enmin Xie, Yi Fu, Jingang Zheng^#, Changtao Jiang^#, Jinpeng Sun^# & Wei Kong^#. Sensing ceramides by CYSLTR2 and P2RY6 to aggravate atherosclerosis. Nature. 2025 May;641(8062):476-485. 共同通讯作者，倒数第二位。引用 1次。

8. Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H. Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng^#, Xiao Yu^#, Yan Zhang^#, Jin-Peng Sun^#. Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science. 2023 Apr 7;380(6640):eadd6220. 最后通讯作者，封面文章，高被引论文；引用65次。

9. Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H. Eric Xu^#, Yan Zhang& Jin-Peng Sun^#. Structures of the glucocorticoid-bound adhesion receptor GPR97-G_o complex. Nature. 2021 Jan;589(7843):620-626. 最后通讯作者，高被引论文（2022），引用111次。

10. Lulu Guo, Jie Cheng, Shuo Lian, Qun Liu, Yan Lu, Yuan Zheng, Kongkai Zhu, Minghui Zhang, Yalei Kong, Chao Zhang, Naikang Rong, Yuming Zhuang, Guoxing Fang, Jingjing Jiang, Tianyao Zhang, Xiang Han, Zili Liu, Ming Xia, Shangming Liu, Lei Zhang, Stephen D. Liberles, Xiao Yu, Yunfei Xu^#, Fan Yang^#, Qian Li^# & Jin-Peng Sun^#. Structural basis of amine odorant perception by a mammal olfactory receptor. Nature. 2023 Jun;618(7963):193-200. 最后通讯作者，引用 36次。

11. Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao^# & Jin-Peng Sun^#. Structure, function and pharmacology of human itch receptor complexes. Nature. 2021 Dec;600(7887):164-169. 最后通讯作者，获Nature Chemical Biology专题评述，引用93次。

12. Pan Shang, Naikang Rong, Jing-Jing Jiang, Jie Cheng, Ming-Hui Zhang, Dongwei Kang, Lei Qi, Lulu Guo, Gong-Ming Yang, Qun Liu, Zhenzhen Zhou, Xiao-Bing Li, Kong-Kai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang^#, Qian Li^#, Zhen-Hua Shao^#, Fan Yang^#, and Jin-Peng Sun^#. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell. 2023 Nov 22;186(24):5347-5362.e24. 最后通讯作者，引用16次。

13. Xin Wen, Pan Shang, Haidi Chen, Lulu Guo, Naikang Rong, Xiaoyu Jiang, Xuan Li, Junyan Liu, Gongming Yang, Jiacheng Zhang, Kongkai Zhu, Qingbiao Meng, Xuefei He, Zhihai Wang, Zili Liu, Haoran Cheng, Yilin Zheng, Bifei Zhang, Jiaojiao Pang, Zhaoqian Liu, Peng Xiao, Yuguo Chen, Lunxu Liu, Fengming Luo, Xiao Yu, Fan Yi^#, Pengju Zhang^#, Fan Yang^#, Cheng Deng^#, and Jin-Peng Sun^#. Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4. Cell. 2025 Feb 6;188(3):653-670.e24. 最后通讯作者，获Mol Cell杂志专题评论，引用3次。

14. Yu-Qi Ping, Peng Xiao, Fan Yang, Ru-Jia Zhao, Sheng-Chao Guo, Xu Yan, Xiang Wu, Chao Zhang, Yan Lu, Fenghui Zhao, Fulai Zhou, Yue-Tong Xi, Wanchao Yin, Feng-Zhen Liu, Dong-Fang He, Dao-Lai Zhang, Zhong-Liang Zhu, Yi Jiang, Lutao Du, Shi-Qing Feng, Torsten Schöneberg, Ines Liebscher^#, H. Eric Xu^# & Jin-Peng Sun^#. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770. 最后通讯作者，高被引论文，Nature配发同期评述，引用68次。

15. Peng Xiao, Shengchao Guo, Xin Wen, Qing-Tao He, Hui Lin, Shen-Ming Huang, Lu Gou, Chao Zhang, Zhao Yang, Ya-Ni Zhong, Chuan-Cheng Yang, Yu Li, Zheng Gong, Xiao-Na Tao, Zhi-Shuai Yang, Yan Lu, Shao-Long Li, Jun-Yan He, Chuanxin Wang, Lei Zhang^#, Liangliang Kong^#, Jin-Peng Sun^#, Xiao Yu^#. Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4. Nature. 2022 Apr;604(7907):771-778. 共同通讯作者，倒数第二位。高被引论文，引用78次。

16. Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao, Kai Wang, Mingxin Gao, Xuemei Wang, Weixuan Chen, Chuyu Yun, Chuan Ye, Jinkun Xu, Weike Shaoyong, Lijun Zhang, Pan Shang, Xi Luo, Zhiwei Zhang, Xin Zheng, Xueying Sha, Jinxin Zhang, Shaoping Nie, Xuguang Zhang, Fazheng Ren, Huiying Liu, Erdan Dong, Xiao Yu^#, Linong Ji^#, Yanli Pang^#, Jin-Peng Sun^#, and Changtao Jiang^#. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE. Cell. 2025 10.1016/j.cell.2025.05.010. 共同通讯作者，倒数第二。

17. Zheng Xu, Lulu Guo, Jingjing Yu, Siyuan Shen, Chao Wu, Weifeng Zhang, Chang Zhao, Yue Deng, Xiaowen Tian, Yuying Feng, Hanlin Hou, Lantian Su, Hongshuang Wang, Shuo Guo, Heli Wang, Kexin Wang, Peipei Chen, Jie Zhao, Xiaoyu Zhang, Xihao Yong, Lin Cheng, Lunxu Liu, Shengyong Yang, Fan Yang, Xiaohui Wang, Xiao Yu^#, Yunfei Xu^#, Jin-Peng Sun^#, Wei Yan^#, Zhenhua Shao^#. Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature. 2023 Dec;624(7992):672-681.共同通讯作者，倒数第三位。Nature配发同期评述，引用26次。

18. Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun^#, Xin Xie^#, Xiao Yu^# & Yan Zhang^#. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Nov;587(7834):499-504.共同通讯作者，倒数第4位。引用121次。

19. Xiaolong Hu, Weizhen Ao, Mingxin Gao, Lijie Wu, Yuan Pei, Shenhui Liu, Yiran Wu, Fei Zhao, Qianqian Sun, Junlin Liu, Longquan Jiang, Xin Wang, Yan Li, Qiwen Tan, Jie Cheng, Fan Yang, Chi Yang^#, Jinpeng Sun^#, Tian Hua^#, Zhi-Jie Liu^#. Bitter taste TAS2R14 activation by intracellular tastants and cholesterol. Nature. 2024 Jul;631(8020):459-466. 共同通讯作者，倒数第三。引用18次。

20. Peng Xiao, Wei Yan, Lu Gou, Ya-Ni Zhong, Liangliang Kong, Chao Wu, Xin Wen, Yuan Yuan, Sheng Cao, Changxiu Qu, Xin Yang, Chuan-Cheng Yang, Anjie Xia, Zhenquan Hu, Qianqian Zhang, Yong-Hao He, Dao-Lai Zhang, Chao Zhang, Gui-Hua Hou, Huanxiang Liu, Lizhe Zhu, Ping Fu, Shengyong Yang, Daniel M Rosenbaum, Jin-Peng Sun^#, Yang Du^#, Lei Zhang^#, Xiao Yu^#, Zhenhua Shao^#. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. 2021 Feb 18;184(4):943-956.e18. 共同通讯作者，倒数第5位。封面文章。引用98次。

21. Jie Cheng, Zhao Yang, Xiao-Yan Ge, Ming-Xin Gao, Ran Meng, Xin Xu, Yu-Qi Zhang, Rui-Zhe Li, Jing-Yu Lin, Zhao-Mei Tian, Jin Wang, Shang-Lei Ning, Yun-Fei Xu, Fan Yang, Jing-Kai Gu, Jin-Peng Sun^#, Xiao Yu^#. Autonomous sensing of the insulin peptide by an olfactory G protein-coupled receptor modulates glucose metabolism. Cell Metabolism. 2022 Feb 1;34(2):240-255. 共同通讯作者，倒数第二位。引用44次。

22. Ting Zhou, Jie Cheng, Shuo He, Chao Zhang, Ming-Xin Gao, Li-Jun Zhang, Jin-Peng Sun^#, Yi Zhu^#, Ding Ai^#. The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid. Nature Metabolism. 2024 Aug;6(8):1566-1583. 共同通讯作者，倒数第三。引用3次。

23. Jia-Le Wang, Xiao-Dong Dou, Jie Cheng, Ming-Xin Gao, Guo-Feng Xu, Wei Ding, Jin-Hui Ding, Yu Li, Si-Han Wang, Zhao-Wei Ji, Xin-Yi Zhao, Tong-Yu Huo, Cai-Fang Zhang, Ya-Meng Liu, Xue-Ying Sha, Jia-Rui Gao, Wen-Hui Zhang, Yong Hao, Cheng Zhang, Jin-Peng Sun^#, Ning Jiao^#, Xiao Yu^#. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nature Metabolism. 2023 Oct;5(10):1726-1746. 共同通讯作者，倒数第三。引用14次。

24. Jin-Peng Sun#, Peng Xiao, Ines Liebscher^#. The therapeutic potential of orphan adhesion G-protein-coupled receptors. Nature reviews. Drug discovery, 2026, Advance online publication. 第一兼通讯作者。引用0次。

25. Zhao Yang, Jun-Yan Wang, Fan Yang, Kong-Kai Zhu, Guo-Peng Wang, Ying Guan, Shang-Lei Ning, Yan Lu, Yu Li, Chao Zhang, Yuan Zheng, Shu-Hua Zhou, Xin-Wen Wang, Ming-Wei Wang, Peng Xiao, Fan Yi, Cheng Zhang, Peng-Ju Zhang, Fei Xu, Bao-Hua Liu, Hua Zhang, Xiao Yu^#, Ning Gao^#, Jin-Peng Sun^#. Structure of GPR101-Gs enables identification of ligands with rejuvenating potential. Nature Chemical Biology. 2024 Apr;20(4):484-492. 最后通讯作者，引用13次。

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52. Yujia Li, Yiqi Duan, Qingqing Chu, Hang Lv, Jing Li, Xiangyun Guo, Yanjiao Gao, Min Liu, Wei Tang, Huili Hu, Hong Liu, Jinpeng Sun^#, Xiaojie Wang^# and Fan Yi^#. G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease. Kidney Int. 2025 Apr;107(4):652-665.共同通讯作者，倒数第三位。本文获杂志同期评述。

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54. Shenming Huang, Peng Xiao, Jin-Peng Sun^#. Structural basis of signaling of cannabinoids receptors: paving a way for rational drug design in controling mutiple neurological and immune diseases. Signal Transduction and Targeted Therapy. 2020 Jul 21;5(1):127. 最后通讯作者，引用7次。

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73. Kangshuai Li, Xuben Hou, Ruirui Li, Wenxiang Bi, Fan Yang, Xu Chen, Peng Xiao, Tiantian Liu, Tiange Lu, Yuan Zhou, Zhaomei Tian, Yuemao Shen, Yingkai Zhang, Jiangyun Wang, Hao Fang, Jinpeng Sun^#, and Xiao Yu^#. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. Journal of Biological Chemistry. 2019 May 24;294(21):8653-8663.共同通讯作者，倒数第二位。引用10次。

74. Yujing Sun, Daolai Zhang, Ming-Liang Ma, Hui Lin, Youchen Song, Junyan Wang, Chuanshun Ma, Ke Yu, Wentao An, Shengchao Guo, Dongfang He, Zhao Yang, Peng Xiao, Guige Hou, Xiao Yu^#, and Jin-Peng Sun^#. Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. Journal of Biological Chemistry. 2021 Jan-Jun;296:100174. 最后通讯作者，引用21次。

75. Jing-Yu Lin, Zhao Yang, Chan Yang, Ji-Xiang Du, Fan Yang, Jie Cheng, Wei Pan, Shi-Jie Zhang, Xu Yan, Jia Wang, Jin Wang, Lu Tie, Xiao Yu^#, Xin Chen^#, and Jin-Peng Sun^#. An ionic lock and a hydrophobic zipper mediate the coupling between an insect pheromone receptor BmOR3 and downstream effectors. Journal of Biological Chemistry. 2021 Oct;297(4):101160. 最后通讯作者，引用3次。

76. Duxiao Yang, Peng Xiao, Qing Li, Xiaolei Fu, Chang Pan, Di Lu, Shishuai Wen, Wanying Xia, Dongfang He, Hui Li, Hao Fang, Yuemao Shen, Zhigang Xu, Amy Lin, Chuan Wang, Xiao Yu, Jiawei Wu^#, and Jin-Peng Sun^#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation. Journal of Biological Chemistry. 2018 Oct 19;293(42):16226-16241. 最后通讯作者，引用5次。

77. Qiao-Xia Hu, Jun-Hong Dong, Hai-Bo Du, Dao-Lai Zhang, Hong-Ze Ren, Ming-Liang Ma, Yuan Cai, Tong-Chao Zhao, Xiao-Lei Yin, Xiao Yu, Tian Xue, Zhi-Gang Xu^#, and Jin-Peng Sun^#. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. Journal of Biological Chemistry. 2014 Aug 29;289(35):24215-24225. 最后通讯作者，引用58次。

部分大会口头报告及特邀报告：

1. 受邀参加第十九届世界基础与临床药理学大会(19thWorld Congress of Basic & Clinical Pharmacology)担任Section Chair (Drug development according to signaling diversities of GPCRs)并作主题报告。2023年

2. 受邀参加第十一届国际黏附类受体会议(The 11th International Adhesion GPCR Workshop)并作报告。2024年

3. 受邀参加4GPCRnet国际研讨会并作报告。2022年

4. 受邀作为特邀嘉宾参加国际糖尿病与代谢大会并作报告。2024年

5. 受邀作为特邀嘉宾参加亚洲药学科学联合国际会议并作报告。2017年

6. 受邀参加第八届国际离子会议并作报告。2021年

7. 受邀参加第2届SMART研讨会（The 2nd SMART symposium）并作报告。2023年

8. 受邀参加“膜蛋白结构生物学和药物发现创新前沿”会议（2025 Frontiers in Membrane Protein Structural Biology and Drug Discovery Innovation），并作为特邀讲者作报告。2025年

9. 受邀参加“第十九届东方心脏病学会议”并作报告。2025年

10. 受邀参加第29届生物化学家与分子生物学家联盟会议并作报告。2022年

11. 受邀参加“大脑与内分泌：回归基础研究”研讨会并作报告。2024年

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